Product Description Vitamin C is a water-soluble nutrient with revered antioxidant and immune-supportive properties.* DIRECTIONS Apply patch daily to an area with little or no hair, i.e., shoulder, back or hip. For best results, it is recommended to wear PatchMD patches for 8 hours. There is no additional benefit wearing the patch longer than 8 hours. Patches can be worn during sleep. Avoid using any lotion or cream in the same area as it will inhibit absorption. Vitamin C Patch is not waterproof. It is ok to wear multiple patches at a time. PatchMD products are Latex, Lactose., Gluten and Sugar-free